蓝海人类学在线 Ryan WEI's Forum of Anthropology

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发表于 2018-3-26 10:32 | 显示全部楼层 |阅读模式
Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals

AbstractAncient DNA is revealing new insights into the genetic relationship between Pleistocene hominins and modern humans. Nuclear DNA indicated Neanderthals as a sister group of Denisovans after diverging from modern humans. However, the closer affinity of the Neanderthal mitochondrial DNA (mtDNA) to modern humans than Denisovans has recently been suggested as the result of gene flow from an African source into Neanderthals before 100,000 years ago. Here we report the complete mtDNA of an archaic femur from the Hohlenstein-Stadel (HST) cave in southwestern Germany. HST carries the deepest divergent mtDNA lineage that splits from other Neanderthals ∼270,000 years ago, providing a lower boundary for the time of the putative mtDNA introgression event. We demonstrate that a complete Neanderthal mtDNA replacement is feasible over this time interval even with minimal hominin introgression. The highly divergent HST branch is indicative of greater mtDNA diversity during the Middle Pleistocene than in later periods.
 楼主| 发表于 2018-3-26 10:33 | 显示全部楼层 ... 8af8f3edfbcec60d854

德国蒂宾根大学的Cosimo Posth, Johannes Krause和他们的同事重新建立了一根从德国西南部Hohlenstein–Stadel洞穴中发现的古代股骨的完整线粒体DNA基因组。这一样本呈现了至今找到的尼安德特人线粒体DNA中年代最久远的分支。这项发现表明晚更新世尼安德特人的线粒体DNA起源于27万年前来自非洲的基因流动,而这些尼安德特人的线粒体DNA可能替代了更早期的丹尼索瓦人的线粒体DNA分支。这些发现给我们带来了尼安德特人演化过程的新知识。
 楼主| 发表于 2018-3-26 10:33 | 显示全部楼层
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