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Genome-wide patterns of selection in 230 ancient Eurasians

发表于 2015-11-28 13:27 | 显示全部楼层 |阅读模式
Genome-wide patterns of selection in 230 ancient Eurasians
Abstract• Accession codes• References• Author information• Extended data figures and tables• Supplementary information
Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 BC, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe’s first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 BC, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.
发表于 2018-1-21 18:46 | 显示全部楼层

发表于 2018-4-14 14:53 | 显示全部楼层
We find a surprise in six Scandinavian hunter-gatherers (SHG) from the Motala site in southern Sweden. In three out of six samples, we observe the haplotype carrying the derived allele of rs3827760 in the EDAR gene (Extended Data Fig. 5), which affects tooth morphology and hair thickness33,34, has been the subject of a selective sweep in East Asia35, and today is at high frequency in East Asians and Native Americans. The EDAR derived allele is largely absent in present-day Europe except in Scandinavia, plausibly due to Siberian movements into the region millennia after the date of the Motala samples. The SHG have no evidence of East Asian ancestry4,7, suggesting that the EDAR derived allele may not have originated not in East Asians as previously suggested35. A second surprise is that, unlike closely related western hunter-gatherers, the Motala samples have predominantly derived pigmentation alleles at SLC45A2 and SLC24A5.
发表于 2018-4-14 14:54 | 显示全部楼层
发表于 2018-4-15 12:38 | 显示全部楼层
skyyrie 发表于 2018-4-14 14:54


发表于 2018-4-15 12:48 | 显示全部楼层
skyyrie 发表于 2018-4-14 14:54

    前年我也曾经推测北欧Motala古人的EE血统颇高,以为可以达到接近一半,不过去年底看了最新的检测结果,知道是一种错觉。  EDAR上的某些亚美大人种特异allele频度高,不代表一定是EE血统多,二者还是具有相当的独立性的。  因此我认为还是回到我前年最早的判别标准,判定一个族群是否属于亚美大人种的标准是:EE>50%+370A>50%

发表于 2018-4-15 13:32 | 显示全部楼层
发表于 2018-4-15 20:43 | 显示全部楼层

一统浆糊 发表于 2018-4-15 12:38

肯定是从东南亚过去的啊,K P的最初分化地都在东南亚
发表于 2018-4-15 20:44 | 显示全部楼层
根据动物实验,370A变异与直发密切相关, ...
imvivi001 发表于 2018-4-15 13:32

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