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蓝海人类学在线 Ryan WEI's Forum of Anthropology

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Genome-wide patterns of selection in 230 ancient Eurasians

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发表于 2015-11-28 13:27 | 显示全部楼层 |阅读模式
Genome-wide patterns of selection in 230 ancient Eurasians
Abstract
Abstract• Accession codes• References• Author information• Extended data figures and tables• Supplementary information
Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 BC, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe’s first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 BC, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.


http://www.nature.com/nature/journal/vaop/ncurrent/full/nature16152.html#tables
发表于 2018-1-21 18:46 | 显示全部楼层
非常好的一篇研究成果,而且还是包括Mathi在内的众多欧美大牛组成的超豪华团队的研究成果,第一次全面揭开新石器伊始至铁器早期西亚欧人群的基因结构。

     当然,瑕不掩瑜之处也是存在的,比如选取了一个八千年前的西欧古人作为WHG的代表,这显然是不合适的,因为此时小亚的农夫已经开始殖民西欧,此时的西欧土著的血统已经不是很纯了(更何况还存在新仙女木之后欧洲土著从小亚避难所回流的因素),因此造成这个‘代表’反而不如明显混有ANE成分的东欧EHG,导致文中的ADNIXTURE分析结果出现WHG成分peak出现在EHG人群中而不是WHG自身的奇观,最终导致整个ADM分析结果出现偏差,也是早期ADM运用者们难免的学习代价吧。
发表于 2018-4-14 14:53 | 显示全部楼层
We find a surprise in six Scandinavian hunter-gatherers (SHG) from the Motala site in southern Sweden. In three out of six samples, we observe the haplotype carrying the derived allele of rs3827760 in the EDAR gene (Extended Data Fig. 5), which affects tooth morphology and hair thickness33,34, has been the subject of a selective sweep in East Asia35, and today is at high frequency in East Asians and Native Americans. The EDAR derived allele is largely absent in present-day Europe except in Scandinavia, plausibly due to Siberian movements into the region millennia after the date of the Motala samples. The SHG have no evidence of East Asian ancestry4,7, suggesting that the EDAR derived allele may not have originated not in East Asians as previously suggested35. A second surprise is that, unlike closely related western hunter-gatherers, the Motala samples have predominantly derived pigmentation alleles at SLC45A2 and SLC24A5.
发表于 2018-4-14 14:54 | 显示全部楼层
斯堪的纳维亚中的Motala遗骨6个中有3个检测出东亚型的EDAR基因,看来原始的斯堪的纳维亚狩猎采集者长相可能很东亚
发表于 2018-4-15 12:38 | 显示全部楼层
斯堪的纳维亚中的Motala遗骨6个中有3个检测出东亚型的EDAR基因,看来原始的斯堪的纳维亚狩猎采集者长相可能很东亚
skyyrie 发表于 2018-4-14 14:54


这只能说明东亚人来自北欧。别问我为什么。

40000年前的田园洞人也是来自35000年前的GoyetQ116-1。这个可以解释,他们可以跑过来么。至于年代的问题,只要速度足够快,时光可以倒转,这可是爱因斯坦说的。
发表于 2018-4-15 12:48 | 显示全部楼层
斯堪的纳维亚中的Motala遗骨6个中有3个检测出东亚型的EDAR基因,看来原始的斯堪的纳维亚狩猎采集者长相可能很东亚
skyyrie 发表于 2018-4-14 14:54
.

    前年我也曾经推测北欧Motala古人的EE血统颇高,以为可以达到接近一半,不过去年底看了最新的检测结果,知道是一种错觉。  EDAR上的某些亚美大人种特异allele频度高,不代表一定是EE血统多,二者还是具有相当的独立性的。  因此我认为还是回到我前年最早的判别标准,判定一个族群是否属于亚美大人种的标准是:EE>50%+370A>50%
(另外需要鉴别的是,EDAR上的allele也不一定是完全同频度的,有一些allele频度高不代表370A频度也是一样高)

新石器-北欧-K20-17-2017-12.png
发表于 2018-4-15 13:32 | 显示全部楼层
目前为止,不算东斯拉夫摩尔多瓦这些东亚欧血统相对较多的欧洲族群,北欧人中芬兰人的EE血统也是比较明显的,主要是EAN成分,约一成多,这个倒是与他们的370A频度基本一致。
根据动物实验,370A变异与直发密切相关,这个与欧洲人中北欧人的直发率较高基本一致,不过我们知道,北欧人的直发率明显大于他们的370A变异频度,提示决定直发的功能性allele应该不止一个~~
发表于 2018-4-15 20:43 | 显示全部楼层
这只能说明东亚人来自北欧。别问我为什么。

40000年前的田园洞人也是来自35000年前的GoyetQ116-1。这个可以解释,他们可以跑过来么。至于年代的问题,只要速度足够快,时光可以倒转,这可是爱因斯坦说的。
一统浆糊 发表于 2018-4-15 12:38


肯定是从东南亚过去的啊,K P的最初分化地都在东南亚
发表于 2018-4-15 20:44 | 显示全部楼层
目前为止,不算东斯拉夫摩尔多瓦这些东亚欧血统相对较多的欧洲族群,北欧人中芬兰人的EE血统也是比较明显的,主要是EAN成分,约一成多,这个倒是与他们的370A频度基本一致。
根据动物实验,370A变异与直发密切相关, ...
imvivi001 发表于 2018-4-15 13:32


北部这些人史前很能跑的,毕竟么有特别高的山和河流挡着路
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