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Y-SNP单倍群 G 的系统树得到更新

发表于 2009-6-27 21:51 | 显示全部楼层 |阅读模式
PLoS ONE doi:10.1371/journal.pone.0005792.g001

Improved Resolution Haplogroup G Phylogeny in the Y Chromosome, Revealed by a Set of Newly Characterized SNPs

Lynn M. Sims et al.



Y-SNP haplogroup G (hgG), defined by Y-SNP marker M201, is relatively uncommon in the United States general population, with only 8 additional sub-markers characterized. Many of the previously described eight sub-markers are either very rare (2–4%) or do not distinguish between major populations within this hg. In fact, prior to the current study, only 2% of our reference Caucasian population belonged to hgG and all of these individuals were in sub-haplogroup G2a, defined by P15. Additional Y-SNPs are needed in order to differentiate between individuals within this haplogroup.

Principal Findings

In this work we have investigated whether we could differentiate between a population of 63 hgG individuals using previously uncharacterized Y-SNPs. We have designed assays to test these individuals using all known hgG SNPs (n = 9) and an additional 16 unreported/undefined Y-SNPS. Using a combination of DNA sequence and genetic genealogy databases, we have uncovered a total of 15 new hgG SNPs that had been previously reported but not phylogenetically characterized. Ten of the new Y-SNPs are phylogenetically equivalent to M201, one is equivalent to P15 and, interestingly, four create new, separate haplogroups. Three of the latter are more common than many of the previously defined Y-SNPs. Y-STR data from these individuals show that DYS385*12 is present in (70%) of G2a3b1-U13 individuals while only 4% of non-G2a3b1-U13 individuals posses the DYS385*12 allele.


This study uncovered several previously undefined Y-SNPs by using data from several database sources. The new Y-SNPs revealed in this paper will be of importance to those with research interests in population biology and human evolution.

Phylogenetic Trees of Haplogroup G.JPG
 楼主| 发表于 2009-6-27 22:03 | 显示全部楼层
原来的系统树。 G的起源之前还有争议,这篇文献对这个问题有所描述。
HG G  Karafet et al. 2008.JPG
发表于 2009-6-28 10:27 | 显示全部楼层
 楼主| 发表于 2009-6-28 11:15 | 显示全部楼层

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发表于 2009-6-28 20:35 | 显示全部楼层
2# ranhaer

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