Google

蓝海人类学在线 Ryan WEI's Forum of Anthropology

 找回密码
 注册
查看: 2738|回复: 0

尼泊尔Tharus人的mtDNA和Y-SNP

[复制链接]
发表于 2010-1-23 15:17 | 显示全部楼层 |阅读模式
BMC Evolutionary Biology 2009, 9:154 doi:10.1186/1471-2148-9-154

Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of
genetic variation

Simona Fornarino,Maria Pala,Vincenza Battaglia,Ramona Maranta,Alessandro Achilli,Guido Modiano,Antonio Torroni,Ornella Semino,Silvana A Santachiara-Benerecetti

Abstract  
Background
Central Asia and the Indian subcontinent represent an area considered as a source and a reservoir for human genetic diversity, with many markers taking root here, most of which are the ancestral state of eastern and western haplogroups, while others are local. Between these two regions, Terai (Nepal) is a pivotal passageway allowing, in different times, multiple population interactions, although because of its highly malarial environment, it was scarcely inhabited until a few decades ago, when malaria was eradicated. One of the oldest and the largest indigenous people of Terai is
represented by the malaria resistant Tharus, whose gene pool could still retain traces of ancient complex interactions. Until now, however, investigations on their genetic structure have been scarce mainly identifying East Asian signatures.
Results   
High-resolution analyses of mitochondrial-DNA (including 34 complete sequences) and Y-chromosome (67 SNPs and 12 STRs) variations carried out in 173 Tharus (two groups from Central and one from Eastern Terai), and 104 Indians (Hindus from Terai and New Delhi and tribals from Andhra Pradesh) allowed the identification of three principal components: East Asian, West Eurasian and Indian, the last including both local and inter-regional sub-components, at least for the Y chromosome.
Conclusions
Although remarkable quantitative and qualitative differences appear among the various population groups and also between sexes within the same group, many mitochondrial-DNA and Y-chromosome lineages are shared or derived from ancient indian haplogroups, thus revealing a deep shared ancestry between Tharus and Indians. Interestingly, the local Y-chromosome Indian component observed in the Andhra-Pradesh tribals is present in all Tharu groups, whereas the inter-regional component strongly prevails in the two Hindu samples and other Nepalese populations.
The complete sequencing of mtDNAs from unresolved haplogroups also provided informative markers that greatly improved the mtDNA phylogeny and allowed the identification of ancient relationships between Tharus and Malaysia, the Andaman Islands and Japan as well as between India and North and East Africa. Overall, this study gives a paradigmatic example of the importance of genetic isolates in revealing
variants not easily detectable in the general population.

发表(免费阅读):http://www.biomedcentral.com/1471-2148/9/154
您需要登录后才可以回帖 登录 | 注册

本版积分规则

小黑屋|手机版|Archiver|人类生物学在线 ( 苏ICP备16053048号 )

GMT+8, 2020-1-19 17:38 , Processed in 0.079418 second(s), 16 queries .

Powered by Discuz! X3.4

© 2001-2017 Comsenz Inc.

快速回复 返回顶部 返回列表