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伊朗人中9 bp del的频率

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发表于 2010-1-16 22:16 | 显示全部楼层 |阅读模式
Distribution of Mitochondrial DNA Intergenic COII/tRNALYS 9 bp  Deletion in Iranian Populations


SA Alemohammad  ,*DD Farhud  ,M Hooshmand  , M Sanati    SJImam  , M Rahmani   ,P Derakhshandeh-Peykar

A 9 bp deletion between cytochrome oxidase subunit II and tRNA Lys genes in mitochondrial DNA, has proven to be an extremely  informative marker for tracing population history. Using the PCR-PAGE and PCR-SSCP techniques in this study, 152 DNA samples  collected from Iranian populations were screened for the 9 bp deletion. No deletion was observed. A length polymorphism, most  probably a 9 bp triplication, was detected in one case. This observation provides further evidence for an ancient migration from  Africa to India through Saudi Arabia, Iraq, Iran and Pakistan. It also supports the hypothesis, which suggested diffusion of Iranian  farmers to India after agricultural revolution. The existence of 9 bp deletions in a background of haplogroup I in Mediterranean and  its absence in Iran, suggests that there is no eastward diffusion of this marker and therefore this haplotype would not be too old. The
presence of 9 bp triplication supports its multiple independent origins.


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