Google

蓝海人类学在线 Ryan WEI's Forum of Anthropology

 找回密码
 注册
查看: 2165|回复: 0

mtDNA单倍群H的结构说明比利牛斯山区是末次盛冰期人类的避难绿岛

[复制链接]
发表于 2009-11-13 22:16 | 显示全部楼层 |阅读模式
The Molecular Dissection of mtDNA Haplogroup H Confirms That the Franco-Cantabrian Glacial Refuge Was a Major Source for the European Gene Pool

Complete sequencing of 62 mitochondrial DNAs (mtDNAs) belonging (or very closely related) to haplogroup H revealed that this mtDNA haplogroup—by far the most common in Europe—is subdivided into numerous subhaplogroups, with at least 15 of them (H1–H15) identifiable by characteristic mutations. All the haplogroup H mtDNAs found in 5,743 subjects from 43 populations were then screened for diagnostic markers of subhaplogroups H1 and H3. This survey showed that both subhaplogroups display frequency peaks, centered in Iberia and surrounding areas, with distributions declining toward the northeast and southeast—a pattern extremely similar to that previously reported for mtDNA haplogroup V. Furthermore, the coalescence ages of H1 and H3 (~11,000 years) are close to that previously reported for V. These findings have major implications for the origin of Europeans, since they attest that the Franco-Cantabrian refuge area was indeed the source of late-glacial expansions of huntergatherers that repopulated much of Central and Northern Europe from ~15,000 years ago. This has also some implications for disease studies. For instance, the high occurrence of H1 and H3 in Iberia led us to re-evaluate the haplogroup distribution in 50 Spanish families affected by nonsyndromic sensorineural deafness due to the A1555G mutation. The survey revealed that the previously reported excess of H among these families is caused entirely by H3 and is due to a major, probably nonrecent, founder event.


发表:http://www.cell.com/AJHG/abstract/S0002-9297(07)63798-7
阅读:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182122/
您需要登录后才可以回帖 登录 | 注册

本版积分规则

小黑屋|手机版|Archiver|人类生物学在线 ( 苏ICP备16053048号 )

GMT+8, 2019-10-15 21:36 , Processed in 0.102699 second(s), 16 queries .

Powered by Discuz! X3.4

© 2001-2017 Comsenz Inc.

快速回复 返回顶部 返回列表