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mtDNA haplogroup C1

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发表于 2010-11-18 22:00 | 显示全部楼层 |阅读模式
mtDNA haplogroup C1 in Icelanders: a genetic mystery

Although most mtDNA lineages observed in contemporary Icelanders can be traced to neighboring populations in the British Isles and Scandinavia, one may have a more distant origin. This lineage belongs to haplogroup C1, one of a handful that was involved in the settlement of the Americas around 14,000 years ago. Contrary to an initial assumption that this lineage was a recent arrival, preliminary genealogical analyses revealed that the C1 lineage was present in the Icelandic mtDNA pool at least 300 years ago. This raised the intriguing possibility that the Icelandic C1 lineage could be traced to Viking voyages to the Americas that commenced in the 10th century. In an attempt to shed further light on the entry date of the C1 lineage into the Icelandic mtDNA pool and its geographical origin, we used the deCODE Genetics genealogical database to identify additional matrilineal ancestors that carry the C1 lineage and then sequenced the complete mtDNA genome of 11 contemporary C1 carriers from four different matrilines. Our results indicate a latest possible arrival date in Iceland of just prior to 1700 and a likely arrival date centuries earlier. Most surprisingly, we demonstrate that the Icelandic C1 lineage does not belong to any of the four known Native American (C1b, C1c, and C1d) or Asian (C1a) subclades of haplogroup C1. Rather, it is presently the only known member of a new subclade, C1e. While a Native American origin seems most likely for C1e, an Asian or European origin cannot be ruled out.


研究结果表明:令人吃惊,冰岛C1的血统不属于已知的四个印第安人(C1b,C1c和C1d)或亚洲(C1a)任何单倍群C1的subclades。相反,它目前是一个新的subclade,C1e唯一的成员。虽然美国本土起源似乎最有可能为C1e,但是亚洲或欧洲的起源,不能排除。
发表于 2010-11-19 00:12 | 显示全部楼层
这的却是个惊人的发现。美洲起源或者欧亚起源皆有可能。
发表于 2010-11-19 00:37 | 显示全部楼层
目前估算的CZ的coalescent time是约6万年左右。。关键是C1本身的年龄问题。如果C1在欧洲大陆普遍缺失,而只出现在冰岛。那么C仍不可能是走经Levant之后的大陆路线,而可能是很早就通过白令海峡到达北美北部然后抵达冰岛。也有可能测序出错。。
发表于 2010-11-19 01:15 | 显示全部楼层
3# 鲜于叔明

此文用的是FGS, 出错是不可能的。
发表于 2013-2-19 16:58 | 显示全部楼层
Lebanese        C        C1        223 266 298 325 327
Lebanese        C        C1        223 266 298 325 327
Bashkir        C        C1        223 298 325 327 362
Bashkir        C        C1        223 298 325 327 362
Bashkir        C        C1        223 298 325 327 362
Icelander        C        C1        223 298 311 325 327
Icelander        C        C1        223 298 311 325 327
Icelander        C        C1        223 298 311 325 327
Thai        C        C1        223 298 311 325 327 357
Indian        C        C1        093 223 298 325 327 362
Indian        C        C1        093 223 298 325 327 362
Indian        C        C1        093 223 298 325 327 362
Indian        C        C1        093 223 298 325 327 362
Indian        C        C1        093 223 298 325 327 362
Indian        C        C1        093 223 298 325 327 362
German        C        C1        223 298 311 325 327
Canary Islander        C        C1        223 298 325 327
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